Best Seller Prolon® Next Gen

SKU PR068A · Fasting Mimicking Diet

Prolon® Next Gen

Name: Prolon® Next Gen
Brand: ProLon® Italia
SKU: PR068A
Price: 229.0 EUR
Availability: InStock

CE-Marked Patented Best Seller

A patented, science-backed program that keeps your body in a fasting state while allowing you to eat nourishing foods. Over five days, your body is rejuvenated at the cellular level, supporting longevity and unlocking powerful health benefits including:

Indication

Metabolic · longevity · weight

Daily Kcal

770–1,100 kcal/day

Cycle Length

5 days

MSRP

€199.00

Ships from Lonso Milan facility · 72h after order confirmation · free cold-chain shipping on orders over €1,500.

Patented FMD ratio

The only fasting-mimicking diet protected by 200+ patents from the Longo Lab. Replicated across 14 RCTs.

Bigger portions, NextGen

More volume per day than the Original. Same patented macro shape — improved adherence and flavour variety.

Reimbursable in 5 EU markets

B07.LE.1 (induction) and B07.LE.2 (maintenance) coding live in Italy, Germany, France, Spain, Netherlands.

How it fits the protocol

Three-cycle induction. Quarterly maintenance.

Induction (3 cycles)

One 5-day cycle per month for three consecutive months. The induction phase delivers the bulk of the biological-age and metabolic-marker effect. Coded B07.LE.1 in Italy.

Maintenance

After induction, one 5-day cycle every three months keeps biomarkers in the improved range. Reimbursable under B07.LE.2 (maintenance protocol).

Between cycles

Patients return to their usual diet — ideally a Mediterranean / longevity pattern. L-Pill, L-Biome, L-Spread and L-Protein support adherence between cycles.

Clinical outcomes — 3 cycles, pooled EU registry

What three cycles do, on the data.

Median body weight

−3.4%

n=423 · 3 cycles

Mean HbA1c

−1.3 pp

n=178 · 12 weeks

Trunk fat

−7.4%

n=144 · 12 weeks

Biological age

−2.5 yrs

Mishra 2024 · n=144

What's in the box

Five labelled day-boxes.
Nothing for the patient to think about.

The NextGen kit ships as five distinct day-boxes, pre-portioned and pre-labelled. Patients open one box at a time — no measuring, no calorie counting, no decisions during the cycle.

Trans.

Ketosis

Autoph.

Renewal

Reset

Biological Age Score · Nature Aging, 2024

Three cycles. 2.5 years younger, on the data.

In the Mishra et al. 2024 trial (n=144, RCT), patients completing three consecutive Prolon FMD cycles reduced their Levine PhenoAge by an average of 2.5 years versus controls.

Read the Trial →

3 yrs

Biological Age Δ

−0.00 pp

HBA1C (12 wk)

−7.4%

Trunk Fat

96%

1st-Cycle Completion

FAQs

What’s different about ProLon Next Gen?

ProLon Next Gen delivers the same science-backed benefits as the original 5-Day Fasting Mimicking Diet, but in an even more convenient, flavor-packed format. The Next Gen kit features certified organic soups and teas that are ready to eat—just pour from the pack and enjoy hot or cold. The soups are made with carefully selected organic vegetables and expert preparation, so patients get the proven FMD experience with less prep and improved taste.

How does the Fasting Mimicking Diet renew my cells?

The program triggers autophagy—the body’s natural cellular cleansing and repair process—during which damaged cell components are broken down and recycled. The ProLon formula was designed to activate autophagy by providing scientifically developed foods that stay below the body’s nutrient-sensing pathways. This allows the sustained benefits of fasting while still nourishing the body.

How do I use ProLon Next Gen?

The ProLon 5-Day FMD kit contains five small boxes, each labeled for one of the five days of the program. Each box includes all the food, beverages, and supplements for that day. A meal card suggests timing, but you choose the consumption order within each day. Items cannot be switched between days, since each day’s plan is precisely calibrated to activate different phases of cellular renewal.

What is the daily caloric intake during ProLon?

Day 1 provides about 1,100 calories (kcal), while Days 2–5 provide between 700 and 800 calories (kcal) per day. Through a precise combination of caloric content and macronutrient ratios, the nutrient-sensing pathways (IGF-1, mTOR and PKA) are kept from being triggered, so metabolic activity continues to mirror a fasted state even with food present.

Will I lose weight on the program?

The average weight loss for program users is about five pounds after one cycle, with waist circumference reduced by roughly 1.5 inches after three cycles. Importantly, the program is designed to target visceral fat while protecting muscle, unlike approaches that cause muscle loss alongside weight reduction.

What happens during the FMD cycle?

Each day activates a different phase of cellular renewal. Day 1: the body transitions to fasting mode and begins depleting glucose stores. Day 2: fat-burning is in full effect through ketosis, while muscle is preserved. Day 3: autophagy begins as the body transitions into its cellular cleanup state. Day 4: a heightened state of cellular rejuvenation with peak fat-burning. Day 5: cellular transformation completes, with younger, high-functioning components replacing old cells.

What are the food pathways affected by ProLon?

ProLon downregulates three primary nutrient-sensing pathways: IGF-1, mTOR and PKA. PKA responds primarily to sugar and carbohydrates, while IGF-1 is primarily responsive to protein (and more strongly triggered by animal protein), and mTOR is triggered by IGF-1 and amino acids. Keeping these pathways below their activation thresholds is what allows the body to stay in a fasted state while still being nourished.

Complete the Protocol